Veterinary Allergy PDF. The term ‘allergy’ was introduced by the Austrian physician Clemens von Pirquet in 1906, however with a somewhat different meaning to that of today.
Veterinary Allergy PDF
He was studying the immune response to tuberculosis and diphtheria, and was thus working at the interface between immunity and hypersensitivity. He proposed the use of the term ‘allergy’ to imply ‘altered reactivity’ in the host. Thus allergy was not a disease per se, but rather a state that would result in a hypersensitivity reaction if appropriately challenged. This concept was gradually discarded despite some attempts to keep it alive.
Tremendous advances in the understanding of the science behind allergy in man—now used synonymously with hypersensitivity, were made between 1920 and 1940. Notable were the studies by Prausnitz and Küstner who described the skin-sensitizing antibody that was responsible for many allergic reactions.
Then in the 1930s Coca introduced the term ‘atopy’ which was derived from the Greek and translated literally as ‘strange disease’, to encompass the triad of the familial diseases of allergic asthma, allergic rhinitis, and atopic dermatitis. They also applied the term ‘reagin’ to the skin-sensitizing antibody of Prausnitz and Küstner.
Anyone who reads these early publications cannot but marvel at the painstaking and insightful work, undertaken without the aid of modern-day techniques and at the generally sound conclusions that were reached. The next major step forward was the demonstration by Ishizaka and colleagues that the reagin belonged to a hitherto undescribed antibody class that they termed ‘IgE’.
The current state of knowledge on this increasingly important subject is beautifully described in this, the first truly comprehensive text of allergic diseases affecting the major veterinary species. It will be an invaluable guide to students, clinicians and researchers alike. However, most importantly, whilst it quite naturally concentrates on what is known, it also draws attention to what is not yet known. In so doing it will hopefully provide the necessary stimulus for future research so that this fascinating subject will continue to advance.
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