A Toxicologist’s Guide to Clinical Pathology in Animals
A Toxicologist’s Guide to Clinical Pathology in Animals. For many toxicologists, the evaluation of hematology, clinical chemistry, and urinalysis data can be the most daunting part of animal toxicity studies. When dozens of parameters are measured for each animal at regular intervals throughout a study, there may be hundreds or even thousands of data points to consider.
What does it mean when a parameter value increases for an individual or for a group? What does it mean when it decreases? When a parameter change is statistically signiﬁcant does that mean it is biologically signiﬁcant? What other parameters can be used to strengthen a diagnosis? What is causing these changes? The answers to these questions can be found in veterinary clinical pathology textbooks, of course, and every toxicologist should own at least one or two; but searching for diagnostic information in textbooks can be difﬁcult and time consuming.
Many years ago, I began keeping a notebook of key information and diagnoses for the clinical pathology parameters used in toxicology studies. As my notebook grew over the years into a handbook, I shared more than 150 copies with my fellow toxicologists. It is because of their favorable reviews and encouragement that my handbook has now been published.
The intent of this handbook is to provide a user-friendly resource that puts the most relevant information at your ﬁngertips. It is written as one toxicologist to another. I sincerely hope you ﬁnd this handbook to be useful.
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