Pathology of Genetically Engineered and Other Mutant Mice

Pathology of Genetically Engineered and other Mutant Mice

by Peter Vogel, John P. Sundberg, Jerrold M. Ward, Published: 2022, FileType: PDF

An updated and comprehensive reference to pathology in every organ system in genetically modified mice. The newly revised and thoroughly updated Second Edition of Pathology of Genetically Engineered and Other Mutant Mice delivers a comprehensive resource for pathologists and biomedical scientists tasked with identifying and understanding pathologic changes in genetically modified mice. The book is organized by body system, and includes descriptions and explanations of a wide range of findings, as well as hundreds of color photographs illustrating both common and rare lesions that may be found in genetically engineered and wild type mice.

The book is written by experienced veterinary and medical pathologists working in veterinary medical colleges, medical colleges, and research institutes. Covering the latest discoveries in mouse pathology resulting from advancements in biotechnology research over the last 30 years, this singular and accessible resource is a must-read for veterinary and medical pathologists and researchers working with genetically engineered and other mice.

Readers will also benefit from:

• A thorough introduction to mouse pathology and mouse genetic nomenclature, as well as databases useful for analysis of mutant mice
• An exploration of concepts related to validating animal models, including the Cinderella Effect
• Practical discussions of basic necropsy methods and grading lesions for computational analyses
• Concise diagnostic approaches to the respiratory tract, the oral cavity and GI tract, the cardiovascular system, the liver and pancreas, the skeletal system, and other tissues

As a one-stop and up to date reference on mouse pathology, Pathology of Genetically Engineered and Other Mutant Mice is an essential book for veterinary and medical pathologists, as well as for scientists, researchers, and toxicologists whose work brings them into contact with genetically modified mice.

The purpose of this book is to provide a broad overview on how pathologists phenotype mutant and wild- type (without an induced or natural gene mutation) mice and compare them to human diseases. Each chapter covers one organ or organ system with a brief overview of the anatomy, but more importantly, specifics on tissue collection, processing, and special stains or assays used to analyze that particular organ. Each chapter is written by one or more experts on that organ. In so doing, this book provides a useful starting point for investigators working with mice, be they experts or neophytes.

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