Essentials of Mucosal Immunology PDF. The mucosal immune system is considered by many to be a “new world” in the area of immunology and has numerous unique features compared to the classical systemic immune compartment.
Essentials of Mucosal Immunology PDF
For example, the mucosal immune system consists of specialized lgA inductive and effector sites, as well as unique cell trafficking patterns that underlie the common mucosal immune system (CMIS). Secretory IgA is the major antibody produced at mucosal surfaces and plays an important role in recognition and protection against non-self antigens in those sites.
The poly immunoglobulin receptor that transports lgA across epithelial cells has become a basis for the study of membrane receptor trafficking by cell biologists and immunologists alike. a{3 and -y8 T cells reside within the mucosal epithelial layer (i.e., intraepithelial lymphocytes) as well as in the lamina propria region of the mucosa, where they represent a key arm of the cellular immune system.
These specialized T cells participate in the induction and regulation of antigen-specific lgA B-cell and effector T-cell responses. Furthermore, epithelial cells that line mucosal surfaces are themselves an integrated component of the mucosa! immune system and provide signals important for initiation of the mucosal inflammatory response and key cell-cell communication between epithelial cells and mucosa! lymphoid cells.
The concept of the CMIS has provided a rational basis for the clinical development of mucosa! vaccines for the prevention of infectious diseases, and mucosally induced tolerance has provided a therapeutic basis for the prevention and treatment of autoimmune disease and tissue rejection in organ transplantation. Thus, mucosa! immunology is an exciting area for both basic and clinical scientists interested in the field of immunology.
File Size: 23.2 MB
File Type: PDF
