Background Lesions in Laboratory Animals A Color Atlas, Evaluating the pathology of tissues involves not only the recognition of lesions caused directly by treatment or disease but also the identification of background lesions.
Background Lesions in Laboratory Animals A Color Atlas
An experienced pathologist should be familiar with the spontaneous, incidental background lesions present in a particular organ or tissue (Shackleford et al 2002). Toxicologic patholoÂgists need to be able to recognize background lesions in animals of different ages so that these changes are not incorrectly attributed to the test article. Toxicologists and regulators are understandably keen to ensure that background findings are not incorrectly attributed to test article effects. This book is for veterinary and toxicologic pathologists, at all stages of their training or career, who want to know more about background lesions in laboratory animals.
This atlas describes background lesions and illustrates most of them with a color image. There are chapters on each of the major species of laboratory animal commonly used in toxicology studies, with a complete, well organized description of the background changes expected for each of the major organ systems. There is also a chapter on background lesions in the reproductive system of all laboratory animals; the reproductive system is discussed separately from the other organ systems because of the considerable number of background lesions in the reproductive tissues encountered due to normal physiology, housing conditions and the impact of age (i.e. before or after the onset of puberty).
Evaluation of the reproductive system in nonÂhuman priÂmates can be difficult owing to the small sample sizes and the timing around puberty which can result in a large number of background lesions that may mimic testÂarticleÂrelated findings; the reproductive chapter contains detailed descriptions of the hormonal changes recorded in female nonÂhuman primates, dogs and rodents. Finally, there is also a chapter on artifacts caused during the death process (agonal) and during the processing of tissues. The book is fully referenced.
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